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Although this kinase was shown to regulate plasma membrane trafficking of NKCC2 in vitro (Fillon et al., 2001), the specific role of loop diuretics in developing hepatic insulin resistance remains unclear

The pivotal finding is that palmatine orchestrates a coordinated downregulation of this entire network, and this multi-target action functionally converges to suppress the core executioners of hepatocyte apoptosis

That claim rests on animal gut-model data, not on human pharmacokinetic studies

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